Spring Meeting of the Young Researchers of SID, SIIA, SIMI, SIPREC, SISA

Conference report

Chiara Pavanello
Centro Grossi Paoletti, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Italia
Vanessa Bianconi
SC Medicina Interna, Dipartimento di Medicina e Chirurgia, Università degli Studi di Perugia, Italia
Lorenzo Da Dalt
Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Italia
Giovanna Gallo
Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University, Rome, Italy
Costantino Mancusi
Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Italy
Michele Ciccarelli
Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi (SA), Italy
Alessandro Maloberti
Department of Medicine, University of Milano-Bicocca, Milan, Italy; Cardiology 4, "A.De Gasperis" Cardio Center, ASST GOM Niguarda Ca' Granda, Milan, Italy
Francesco Spannella
Internal Medicine and Geriatrics, IRCCS INRCA, Ancona, Italy and Department of Clinical and Molecular Sciences, University "Politecnica Delle Marche", Ancona, Italy
Fabio Fimiani
Unit of Inherited and Rare Cardiovascular Diseases, AORN Dei Colli "V. Monaldi", Naples, Italy
Damiano D’Ardes
Institute of ‘Clinica Medica’, Department of Medicine and Aging Science, ‘G. D’Annunzio’ University of Chieti-Pescara, Italy
Rosa Lombardi
Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy and Medicine and Metabolic Disease Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy
Giovanni Talerico
Internal medicine, Policlinico Casilino, Rome, Italy
Massimiliano Cavallo
Division of Medical Andrology and Endocrinology of Reproduction, University of Perugia and "S. Maria" Hospital, Terni, Italy

Abstract

The VIII Spring Meeting of Young Researchers of the Italian Society of Diabetology (SID), the Italian Society of Arterial Hypertension (SIIA), the Italian Society of Internal Medicine (SIMI), the Italian Society of Cardiovascular Prevention (SIPREC) and the Italian Society for the Study of Atherosclerosis (SISA) “Basic and clinical research: Until grant let us apart” was held in Rimini on April 16-18, 2023. As is customary, the Congress was organized by the young members of the aforementioned scientific societies operating in the cardiometabolic field. The Congress featured five sessions dedicated to the discussion of the recent evidence from both basic and clinical researchers in cardiometabolic treatment and prevention. Many young researchers had the opportunity to present their scientific works in dedicated oral and poster sessions. In this report, we provided a summary of the main issues discussed during the Meeting lectures.

References

  1. Da Dalt L, Ruscica M, Bonacina F, et al. PCSK9 deficiency reduces insulin secretion and promotes glucose intolerance: the role of the low-density lipoprotein receptor. Eur Heart J. 2019;40:357-368. https://doi.org/10.1093/eurheartj/ehy357
  2. Da Dalt L, Castiglioni L, Baragetti A, et al. PCSK9 deficiency rewires heart metabolism and drives heart failure with preserved ejection fraction. Eur Heart J. 2021;42:3078-3090. https://doi.org/10.1093/eurheartj/ehab431
  3. Pirro M, Bianconi V, Paciullo F, et al. Lipoprotein(a) and inflammation: A dangerous duet leading to endothelial loss of integrity. Pharmacol Res. 2017;119:178-187. https://doi.org/10.1016/j.phrs.2017.02.001
  4. Bianconi V, Mannarino MR, Ramondino F, et al. Lipoprotein(a) Does Not Predict Thrombotic Events and In-Hospital Outcomes in Patients with COVID-19. J Clin Med. 2023;12:3543. https://doi.org/10.3390/jcm12103543.
  5. Shirakabe A, Zhai P, Ikeda Y, et al. Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload-Induced Mitochondrial Dysfunction and Heart Failure. Circulation. 2016;133:1249-63. https://doi.org/10.1161/CIRCULATIONAHA.115.020502
  6. Forte M, Marchitti S, Di Nonno F, et al. NPPA/atrial natriuretic peptide is an extracellular modulator of autophagy in the heart. Autophagy. 2023;19:1087-1099. https://doi.org/10.1080/15548627.2022.2115675
  7. Saku K, Yokota S, Nishikawa T, Kinugawa K. Interventional heart failure therapy: A new concept fighting against heart failure. J Cardiol. 2022;80:101-109. https://doi.org/10.1016/j.jjcc.2021.11.018
  8. Stone GW, Abraham WT, Lindenfeld J, et al. Five-Year Follow-up after Transcatheter Repair of Secondary Mitral Regurgitation. N Engl J Med. 2023;388:2037-2048. https://doi.org/10.1056/NEJMoa2300213
  9. Gogiraju R, Bochenek ML, Schäfer K. Angiogenic Endothelial Cell Signaling in Cardiac Hypertrophy and Heart Failure. Front Cardiovasc Med. 2019;6:20. https://doi.org/10.3389/fcvm.2019.00020
  10. Ciccarelli M, Sorriento D, Fiordelisi A, et al. Pharmacological inhibition of GRK2 improves cardiac metabolism and function in experimental heart failure. ESC Heart Fail. 2020;7:1571-1584. https://doi.org/10.1002/ehf2.12706
  11. Messerli FH, Rimoldi SF, Bangalore S. The Transition From Hypertension to Heart Failure: Contemporary Update. JACC Heart Fail. 2017;5:543-551. https://doi.org/10.1016/j.jchf.2017.04.012. Erratum in: JACC Heart Fail. 2017;5:948
  12. Pieske B, Tschöpe C, de Boer RA, et al. How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur Heart J. 2019;40:3297-3317. https://doi.org/10.1093/eurheartj/ehz641. Erratum in: Eur Heart J. 2021;42:1274
  13. Sangineto M, Grabherr F, Adolph TE, et al. Dimethyl fumarate ameliorates hepatic inflammation in alcohol related liver disease. Liver Int. 2020;40:1610-1619. https://doi.org/10.1111/liv.14483
  14. Zhang IW, Curto A, López-Vicario C, et al. Mitochondrial dysfunction governs immunometabolism in leukocytes of patients with acute-on-chronic liver failure. J Hepatol. 2022;76:93-106. https://doi.org/10.1016/j.jhep.2021.08.009
  15. Peiseler M, Schwabe R, Hampe J, et al. Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease - novel insights into cellular communication circuits. J Hepatol. 2022;77:1136-1160. https://doi.org/10.1016/j.jhep.2022.06.012
  16. Pfister D, Núñez NG, Pinyol R, et al. NASH limits anti-tumour surveillance in immunotherapy-treated HCC. Nature. 2021;592:450-456. https://doi.org/10.1038/s41586-021-03362-0
  17. Marrano N, Biondi G, Borrelli A, et al. Irisin and Incretin Hormones: Similarities, Differences, and Implications in Type 2 Diabetes and Obesity. Biomolecules. 2021;11:286. https://doi.org/10.3390/biom11020286
  18. Marrano N, Biondi G, Borrelli A, et al. Type 2 Diabetes and Alzheimer's Disease: The Emerging Role of Cellular Lipotoxicity. Biomolecules. 2023;13:183. https://doi.org/10.3390/biom13010183
  19. Gastaldelli A, Marchesini G. Time for Glucagon like peptide-1 receptor agonists treatment for patients with NAFLD? J Hepatol. 2016;64:262-264. https://doi.org/10.1016/j.jhep.2015.11.031
  20. Mantovani A, Byrne CD, Targher G. Efficacy of peroxisome proliferator-activated receptor agonists, glucagon-like peptide-1 receptor agonists, or sodium-glucose cotransporter-2 inhibitors for treatment of non-alcoholic fatty liver disease: a systematic review. Lancet Gastroenterol Hepatol. 2022;7:367-378. https://doi.org/10.1016/S2468-1253(21)00261-2

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